What It Scores
POYOU is a valid word in the tournament list this site uses. Tile values only, before any premium square: 10 in Scrabble and 12 in Words With Friends. The letters break down as P3 O1 Y4 O1 U1.
Words Made From The Letters In POYOU
15 shorter words come out of these tiles. On a board that matters more than the long play, because a short word on a premium square often beats a long one on plain squares.
4 letter words (1)
3 letter words (6)
2 letter words (8)
Longer Words Containing POYOU
POYOU appears inside each of these, which is what makes it worth knowing as a hook.
Next: the Word Unscrambler for any letters at all. Full entry and definition at Merriam-Webster.