What It Scores
PYXIS is a valid word in the tournament list this site uses. Tile values only, before any premium square: 17 in Scrabble and 18 in Words With Friends. The letters break down as P3 Y4 X8 I1 S1.
Words Made From The Letters In PYXIS
15 shorter words come out of these tiles. On a board that matters more than the long play, because a short word on a premium square often beats a long one on plain squares.
4 letter words (2)
3 letter words (9)
2 letter words (4)
Next: the Word Unscrambler for any letters at all. Full entry and definition at Merriam-Webster.